Q: The proteinuria in the urine routine has changed from 1+ to 2+, does it mean that the disease has worsened? A: Not necessarily. The urine protein in the urine egg gauge is only semi-quantitative and is affected by the specific gravity of the urine, for example, the protein in the urine may not be the same every time during the day and can fluctuate in the range of 1+ to 3+. If you drink less water or sweat more, the urine is more concentrated and the urine protein may change from 1+ to 2+. Therefore, patients with proteinuria should have their 24-hour urine protein series tested regularly to clarify the efficacy of the treatment. Q: What indicators are included in the 24-hour urine protein series and what do they mean? A: The 24-hour total urine protein is an important reference indicator for the evolution of the disease and the determination of the efficacy of the treatment. The analysis of urine protein can provide important information on the site of renal lesion, pathophysiological characteristics of glomerular disease, typing, selection of treatment plan and efficacy judgment, so that adjustments can be made in the prescription of traditional Chinese medicine to target different parts of the injury, especially for those patients who are unable or unwilling to undergo renal puncture, which is of greater significance, as detailed below: Urine microalbumin is Urinary β2 microglobulin is a marker of early diabetic nephropathy and capillary endothelial cell injury; abnormally elevated urinary β2 microglobulin indicates decreased renal tubular reabsorption. Patients with malignancy can also have elevated urinary β2 microglobulin concentrations due to significantly higher blood β2 microglobulin concentrations and filtration exceeding the renal tubular reabsorption capacity, so blood β2 microglobulin can be detected at the same time; urinary α1 microglobulin is a marker of renal tubular proteinuria Urinary α1 microglobulin is a marker of renal tubular proteinuria and is used to assess proximal tubular injury; abnormal urinary NAG activity is a reliable indicator of early tubular impairment. Urinary immunoglobulins can predict clinical remission, renal function and renal tissue damage in patients with nephrotic syndrome, and are an indicator of disease prognosis.