Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia (AML) designated as AML type M by the FAB Collaborative Group. The malignant disease of hematopoietic tissue is characterized by an unrestricted proliferation of suspected leukemic cells in the bone marrow and other hematopoietic tissues and their entry into the peripheral bloodstream, while the production of blood cells in normal patients is significantly suppressed on Wednesdays The disease is the first of the malignant diseases of young people, the cause of which is still incompletely chosen, and the viral poor may be the main cause of the disease, but there are also many factors such as radiation, chemical toxins (benzene) or drugs. According to the degree of immaturity of leukemia cells and the natural course of leukemia, the disease is divided into two main categories: acute and several chronic: typology, acute onset of disease, bone marrow and peripheral blood, and mainly primitive cells. ALL) and acute non-lymphocytic leukemia (ANLL) two categories each with several types currently common domestic and foreign typing as follows: ANLL is divided into type that granulocytic leukemia undifferentiated type (M) granulocytic leukemia partially differentiated type (M) promyelocytic type (M) granulocytic-monocytic type (M) monocytic type (M) red leukemia (M) megakaryocytic type (M); ALL is divided into LL and L type in recent years and according to the immunological characteristics of the cells are divided into TB before B ordinary no money type and undifferentiated type resolute patients often suddenly occur anemia infection and bleeding and liver and spleen lymph node enlargement and sternal pressure pain blood routine and bone marrow examination can determine the diagnosis last recent years Dora efficacy has been greatly improved some patients critical has been cured in addition to blood transfusion and anti-infection and other symptomatic support counseling treatment combined with chemotherapy home is the main symptoms of the current I want to treatment method because really new effective chemotherapy very high drug refusal continues to emerge and the improvement of the combined drug method complete remission rate has reached more than %; in addition differentiation inducer retinoic acid etc. can make promyelocytic leukemia cell differentiation induced maturity efficacy too small significant so-called is fortunately just important discovery in recent years; bone marrow transplantation can be cured at all but there are still some combination problems remain to be solved cardiac epidemiology acute promyelocytic Granulocytic leukemia is not uncommon in too few clinics hard-working patients are often younger median age ~ years old or younger is rare according to Chinese complete statistics the incidence of M is higher than that of western countries % to listen to about account for the same period AML % some areas such as the northeast oil fields M incidence in AML may I want to be as high as % ~ % or even higher foreign data show that the incidence of Latino ethnic groups in Europe Central and South America is higher APL accounts for about The etiology of primary APL is not yet fully understood, but secondary APL is commonly seen in patients with tumors treated with chemotherapy and/or radiation therapy for a long time. The prognosis of secondary APL is similar to that of primary APL, but the AML levels associated with chemotherapy pegging are significantly different. ① early granulocyte plasma is full of abnormal particles; ② often accompanied by bleeding tendency incidence of % to % serious representatives of DIC; ③ % of patients Dr. specific chromosomal t(;)(q; q) changes; ④ sensitive to have seen chemotherapy but high early mortality especially in A cytotoxic cytosolic shielding drug so chemotherapy about % to % of patients contact death from period bleeding; ⑤ vitamin A acid can induce APL cells differentiation maturation arsenic agent can induce their apoptosis; ⑥ duration of remission time experience longer previous depression treatment of APL unfortunately the effect is no money is very poor prognosis vicious mostly due to complications of disseminated intravascular coagulation (DIC) or primary fibrinolysis leading to plus serious bleeding and early death in recent years with the increasing understanding of the characteristics of APL cell biology can be improved and treatment hard method to improve the treatment expression results Specialized and prognosis has been greatly improved early mortality remains significantly reduced clinical appearance performance promyelocytic leukemia (M) bone marrow slice acute promyelocytic leukemia is not clinical manifestations better normal bone marrow hematopoietic failure related manifestations such as anemia bleeding infection; infiltration of leukemia cells related manifestations such as liver spleen and lymph node enlargement bone pain, etc. In addition to these leukemia has the experience of general leukemia manifestations External bleeding tendency is the main clinical feature of the heart of its smile there are % to % of patients easily die from early bleeding diffuse intravascular coagulation (DIC) has a high incidence of about % of awesome patients with DIC complications infection is the most common complication including bacterial viral fungal infections the main try to manifest fever the site of infection is commonly in the oral cavity lung skin severe noble can appear sepsis infection toxic shock DIC is the most important time complication of APL with a high incidence of approximately % of patients ready to occur in recent years with the application of formic acid and arsenic agents the occurrence of DIC has been mainly significantly reduced.