After liver metastasis, there will be different degrees of pain, which is directly related to the individual’s tolerance and the size of the metastatic tumor. Liver metastasis of malignant tumors belongs to the advanced stage of malignant diseases, and patients usually have the symptoms of the primary disease, such as pain in the malignant tumor site, fatigue, lethargy, nausea, vomiting and other symptoms. After liver metastasis, epigastric pain, anorexia, jaundice and other symptoms may appear, and the degree of pain varies greatly among individuals, which is directly related to the sensitivity of individuals. Younger patients may have more severe pain, while older patients may not be sensitive to pain or may not have obvious pain. In addition, there is also a relationship with the size of the tumor. Generally, the larger the tumor, the more severe the pain symptoms. The smaller the tumor, the less severe the pain. This level of pain is generally progressive aggravation, more stubborn, insensitive to general pain medication. Patients should consult the doctor in time, complete the relevant examination, make a clear diagnosis, and then adopt corresponding treatment plan.