Human beings are human beings in society, society is a society of human beings, and human beings play an irreplaceable role in society. People grow from infants to adults, form families, have children and form a small unit in society. This natural phenomenon is a very normal thing for most of them, but for about 15% of them, it is so difficult to have a child. On the road of seeking a child, they have to face external problems such as pressure from work, pain from life, expectation from family, concern from friends, and even ridicule from neighbors, and at the same time, they have to bear the responsibility of their own families, and even many infertility patients have broken up their families. With the progress of society, the development of medicine, and the maturity of technology, the new way to help pregnancy – IVF technology can help more infertile families, bring the gospel, and solve their fertility problems. The following is a typical case that is common in clinical practice but easy to condemn to death. Wang is 26 years old, from Mengjin County. He has been married for one year and has been infertile without contraception. He went to a number of hospitals to check the semen and did not see any sperm. He took traditional Chinese medicine + western medicine for half a year, and still did not see any sperm at the time of rechecking, so he came to our department after being introduced by an acquaintance. Physical examination: bilateral testicular volume of about 15 ml, bilateral epididymal head nodules, no tenderness. Sex hormones were: FSH: 7.37mIU/ML, LH: 5.64mIU/ML, PRL: 8.35ng/ML, T: 4.28ng/ML, E2: 45pg/ML. The proposed diagnosis was: 1) primary infertility, and 2) obstructive azoospermia. He then performed bilateral epididymal fine needle sperm extraction in the afternoon of the same day, and no sperm was seen in the epididymal fluid of both sides. He switched to fine needle sperm extraction of the left testis, and a small amount of testicular tissue was microscopically examined during the operation, no sperm was seen, and the remaining tissue was sent to pathology. The remaining tissue was sent to pathology. In January 2012, the pathology results returned, showing: a little testicular tissue, atrophy of the vas deferens, reduction of spermatogonial cells, and only a few dysplastic spermatozoa were seen. HCG2000U+HMG75U was given to stimulate and promote spermatogenesis in the testis. At the same time, the woman was ovulated and prepared for IVF, and on April 20, 2012, on the same day as the woman’s egg retrieval, the man underwent fine needle spermatogonial retrieval from the testes. After the procedure, single sperm microinjection was performed, and a total of 15 embryos were cultured (2 grade I embryos and 13 grade II embryos), all of which were relatively good embryos. Two embryos were transferred three days later and the remaining 13 embryos were frozen. On May 28, 2012, ultrasound showed that the intrauterine gestational sac was 26.9*12, and the primordial heart tube was pulsating. At present, the patient’s lover has been pregnant for more than 6 months, like this patient, many of them are happy to love their children in our center, and we also hope that we can bring happiness to more infertility patients.