HPV is the human papillomavirus vaccination (HPV), a large family with more than one hundred subtypes, distributed in many parts of the human skin and mucous membranes, both in men and women, most commonly in the oropharynx and anogenital tract. is the most important causative factor for squamous cervical cancer and its precancerous lesions, with high-risk viral infection in almost all (>99.9%) lesions. The majority of oropharyngeal tumors (63%) and almost all anal cancers are also associated with persistent infection with high-risk HPV. The specific types of high-risk HPV remain controversial, with some suggesting as many as 16 species, 13 of which have been identified by WHO as having the most oncogenic potential: types 16, 18, 31, 33, 35, 39, 45, 51, 56, 58, 59 and 68 [4]. Among them, HPV 16 and HPV 18 cause 70% of cervical cancers, while HPV 45 and HPV 31 cause 5% and 10% of cervical cancers, respectively. Low-risk viruses are the causative agents of genital perianal warts, HPV 6 and HPV 11 alone are associated with 90% of genital warts and 96% of acromegaly, but do not cause cancer. Some people think that cervical precancer and cervical cancer go through the “wart” stage, which is a joke, without understanding the classification and typing of HPV. HPV infection is very common and is transmitted through sexual intercourse Human papillomavirus (HPV) is the most common type of pathogen transmitted through sexual intercourse, with a worldwide prevalence of HPV infection of up to 10% [5]. Infection rates are particularly high in young women (45% in women aged 20-24 years in the United States) and decline sharply after the age of 30 years [6]. Therefore large medical guidelines do not recommend routine HPV testing in women under 30 years of age. It is estimated that about half of all men and women have had one lifetime HPV infection [7]. The confirmed modes of transmission are direct mucosa-to-skin and mucosa-to-mucosa contact, including vaginal, anal, and oral intercourse, and there is limited evidence that other modes can be infected with HPV, and one cannot open one’s eyes. The suggestion that one can easily contract warts by wearing a super short skirt on a bus is also a joke, and an obscene one at that, and has been refuted by the professional literature and serious media. Compared to human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2), which are less transmissible pathogens, HPV is highly contagious. The transmission rate from men to women is as high as 0.4 to 0.8 per sexual encounter, and each male sexual partner has a 60% to 80% chance of transmitting HPV16 to women. Any factor related to sexual activity is a high risk factor for HPV infection in the genital tract, including younger age at the start of sexual life, number of sexual partners, recent changes in sexual partners, and sex with someone who has another sexual partner (both male and female) [8]. 2, the vast majority of HPV infections can be cleared in a relatively short period of time The vast majority (more than 95%) of genital tract HPV infections are benign and can clear on their own, with only a small proportion of women becoming persistently infected. The vast majority (more than 80%) of HPV infections can be cleared within a few months (generally within 6-9 months, with an average of 8 months and rarely more than a year), 87% of HPV infections can be cleared within 12 months [9], and 95% of HPV infections can be cleared within 2 years [10-13]. HPV typing is the most important factor in determining whether an infection persists, and factors such as age and sexual life had no significant effect. The time course of HPV infection also varies between types. High-risk viruses seem to persist longer (median 9.3 months) than low-risk HPV (median 8.4 months). hpV16 is most likely to persist (median 12.4 months), but the exact reason for this is unclear, perhaps related to the body’s immune mechanism [14-17]. It has been claimed that the application of nucleoside antivirals can convert 85% of patients within six months, and it is not known what evidence is available. Even if it is true, it is not as brilliant as it could be. This is because doctors who really know the natural history of HPV do not repeatedly go for HPV screening within six months. It is the persistent high-risk type of HPV infection that leads to cervical precancer (cervical intraepithelial neoplasia) and then to the development of invasive cervical cancer. This is a long process and formal screening detects the vast majority (>99.7%) of lesions during this long developmental process [18, 19], which is one of the reasons for the declining incidence of cervical cancer in developed countries. We are also paying increasing attention to the persistence of high-risk HPV infection, but with an emphasis on practical prevention and screening [19]. Because there is no treatment that can completely clear HPV infection. 3, there is no treatment that can completely clear HPV infection There is no effective antiviral treatment for either high-risk types of HPV or low-risk types of HPV, but only for lesions caused by HPV, such as warts in the genital tract and anus, such as precancerous lesions, such as cancer. This has been proven by a large number of studies [20-22]. For warty lesions of the genital tract and anus (e.g., warts), there can be many symptomatic treatment options (freezing, laser, interferon, antiviral drugs, immunotherapy, etc., etc.), but there are still no effective measures or drugs to clear the virus [20-24]. Some may emphasize that these studies are foreign and not representative of the Chinese population, which has a rich Chinese constitution. Well, to date, there is no published literature in mainland China indicating any surgery or medication to clear HPV infection. Studies from Taiwan have also found that topical medications do not clear HPV infections at a rate somewhat faster than the natural clearance rate [25]. Taiwan is also an integral part of China! Based on these perceptions, all slightly more serious articles will not recommend the application of any surgery or drugs to treat HPV infection, let alone solemn evidence-based academic guidelines. The fact that there is no cure for HPV clearance is not a particularly frustrating thing; it is the current state of all viral treatments. We currently have no cure for any of the human viruses, such as hepatitis virus, such as HIV, such as SARS, and we can’t even eradicate cold and flu viruses. Some people compare viral infections of the cervix to viral infections of the throat, and there is truth in that. 4. For lesions caused by high-risk HPV infection, HPV vaccination and formal screening are emphasized For precancerous lesions and cancers caused by high-risk types of HPV, HPV vaccination is recommended first [26-28], and regular, formal screening and treatment is emphasized second [29-34]. Both of these issues are important, so important that there is too much to say to accommodate this small article. HPV vaccines currently on the market are available for two, four, and nine subtypes of HPV [35-37]. However, there is no HPV vaccine available on the mainland, and screening and treatment are in chaos, with sensational and unnecessary treatment and over-care everywhere. The country is in a frenzy, and the wave remains. Because HPV has a high clearance rate, persistent infection is rare, and the prognosis for low-grade cervical lesions is very good, simple HPV infection or even low-grade precancerous lesions (i.e., cervical intraepithelial neoplasia grade 1, CIN1) can be conservatively observed and followed up [38]. gynecologic oncologist for help. This is a much larger topic. Many people think that HPV infection is a direct consequence of “unclean sex” and therefore needs to be treated! The question is, what does “unclean sex” mean? Leaving aside the ignorance of the discipline, this righteous face of moral criticism is laughable. Dr. Lang has always taught us that “HPV infection is not an absolute sign of ‘fidelity’ between sex acts and sexual partners.” “Disease is not God’s punishment of man. Although the occurrence of disease is closely related to human behavior. People with whatever disease should be treated with compassion, care and healing, or at least, doctors should be.”