When the transaminase of drug liver disease reaches a thousand, the drug should be stopped in time and the transaminase should be lowered by general treatment, taking liver-protecting drugs and surgery. 1. General treatment: when the transaminase of drug-related liver disease reaches a thousand, it means that the liver cells have been seriously damaged, and then you need to stop taking the drugs that damage the liver cells in time. At the same time, we should pay attention to develop good living habits, appropriate exercise, avoid staying up late, quit smoking and drinking, and keep a light diet. 2. Drug treatment: patients can take reduced glutathione, polyenyl phosphatidylcholine, S-adenosylmethionine, glycyrrhizic acid preparation and other hepatoprotective drugs to promote hepatocyte repair, so that aminotransferases are reduced. Glucocorticoid drugs such as prednisone can also be taken to inhibit drug-induced immune response and reduce liver cell damage to reduce transaminases. 3. Surgical treatment: If the patient’s liver is severely damaged, surgical treatment such as liver transplantation or artificial liver support therapy can also be considered. Patients with thousands of transaminases from drug-induced liver disease are advised to seek timely medical attention and actively receive treatment. The medication should be taken in strict accordance with the doctor’s instructions, and should not be used on its own, so as not to delay or even aggravate the condition.