Ventricular septal defect is a common congenital heart malformation that can occur alone or in combination with other malformations. Because ventricular septal defect can cause left-to-right shunting at the ventricular level, patients with ventricular septal defect can hear a loud and rough all-systolic murmur with tremor at the 3rd-4th intercostal space on the left border of the sternum. As the pulmonary artery pressure gradually increases, a hyperactive second pulmonary valve heart sound can be heard in the pulmonary valve auscultation area, and as the pressure in the right ventricle gradually increases, the systolic murmur at the left sternal border between the 3rd and 4th ribs gradually decreases. Sometimes a diastolic murmur can be heard due to the presence of secondary pulmonary valve insufficiency. For patients with ventricular septal defects there is an indication to consider giving surgical or transcatheter septal occlusion treatment.