Patient Wang, female, 53 years old, was treated with traditional Chinese medicine for chronic insomnia. On February 28, 2015, her liver function was abnormal: ALT: 840, AST: 805 TBIL: 68.6. DBIL: 32.6. She was hospitalized in a local hospital to exclude viral hepatitis and given liver-protective treatment, intravenous drip compound glycyrrhetinic anhydride, reduced glutathione, and oral eusebioflavine, etc. Her condition gradually worsened. On 20156-1-23 ALT: 399, AST: 477, TBIL: 175, DBIL: 147.Ultrasound: thickened liver parenchyma echogenicity, thickened spleen. Came to the outpatient clinic on 2016-1-26. He complained of high level of fatigue, poor appetite, nausea, aversion to grease, dark yellow urine like strong tea, itchy skin, and sticky and unpleasant stools. The tongue is fat, with a white, thick and greasy tongue coating and a slippery pulse. Chinese medicine identification: damp-heat blockage and weakness of spleen qi Treatment: clear heat and dampness, strengthen spleen and benefit qi. The patient was examined as follows: after one month of treatment the condition improved significantly, and there was no intravenous infusion in the process. The patient is a middle-aged female with a history of long-term drug use, laboratory tests exclude viral hepatitis and autoimmune liver disease, liver function is obviously abnormal, PTA has not significantly decreased, elevated serum bilirubin is dominated by elevated direct bilirubin, ALP and GGT are significantly elevated, the diagnosis is considered drug-related hepatitis is likely. Cholestasis. The patient was hospitalized for nearly a month with progressive worsening of her condition, manifested by rising jaundice. After discharge from the hospital, she was treated with Chinese herbal medicine for more than one month, and the jaundice subsided significantly, and the liver function indexes improved comprehensively, and she continues to be followed up.