Blisters on the soles of the feet (commonly referred to as blisters in clinical practice) can be classified as physiological or pathological. If the blisters are due to physiological factors such as discomfort in walking shoes or excessive friction on the soles of the feet due to prolonged walking, they can be treated by cleaning and disinfection. If it is due to pathological factors, such as blisters from burns, tinea pedis, sweat blisters, keratolytic disease and other causes of blisters, it is necessary to seek active medical treatment to avoid aggravation of the condition. I. Physiological factors: If the blister is caused by mechanical friction, you can usually try to treat it yourself. 1. Rinse: Clean the skin around the blister with water or soapy water; 2. Disinfection: Disinfect the surface of the blister with iodophor, and it is recommended to wipe it twice to ensure the disinfection effect; 3. Puncture: Use a needle disinfected with iodophor and subsequently puncture it at the blister to facilitate the drainage of the internal fluid, and care should be taken to Ensure that the liquid is completely discharged and that the skin on the surface of the blister is left in place; 4, bandage: wrap the wound with clean gauze to prevent infection. The actual fact is that you can find a lot of people who have been in the business for a long time. You can first wet compress the infected area with boric acid solution, and after the local rash dries and converges, then use strong penetrating antifungal drugs for topical rubbing, such as terbinafine, bifenazole cream, etc.; 3, sweat blisters: blistering skin disease that easily occurs on the feet, with a certain burning and itching sensation. It is usually able to subside on its own within a few weeks, but those with other uncomfortable symptoms need prompt treatment. Oral loratadine, prednisone and other drugs can be taken to help relieve itching, or tacrolimus ointment can be used to relieve skin swelling and irritation; 4. Keratosis pilaris: hyperkeratosis of the skin on the palms of the hands and feet bilaterally, which will initially appear as pinhead-sized white blisters. Emollient creams and keratin softening creams are commonly used to relieve the symptoms of dry keratinization, and severe cases should be combined with vitamin A and vitamin E supplements.