Lin Lin, 5 years old, was found to have a heart murmur during a physical examination and was clearly diagnosed as having an intra-crestal ventricular septal defect by cardiac ultrasonography. According to the previous experience and the accepted treatment guidelines in China, minimally invasive interventional occlusion is not recommended for intracrural ventricular septal defects. The child’s parents approached me through a friend and expressed their strong desire to treat the child’s ventricular septal defect with a minimally invasive interventional procedure. I again performed an ultrasound examination of the child’s heart and found that it was indeed a crestal intraventricular septal defect, very close to the aortic valve, with a septum of about 4 mm from the pulmonary valve. After careful communication with the child’s parents, I decided to try to treat Linlin’s ventricular septal defect with a minimally invasive interventional blocking technique. If the minimally invasive intervention was unsuccessful, it was transferred directly to the surgical operating room for surgical repair by the chief of cardiac surgery. In the DSA operating room, a special body position left ventriculogram was first performed, which showed a 3.7 mm septal defect, located under the aortic valve. Then, after two hours of effort, a right femoral vein-right atrium-right ventricle-ventricular septal defect-left ventricle-right femoral artery track was finally established. The “6mm eccentric septal blocker” produced by Shenzhen Centric Technology was selected to block the septum successfully at one time. After left ventriculography and supra-aortic angiography again, it showed no residual shunt and no aortic regurgitation. Cardiac ultrasound showed good position of the blocker, no residual shunt at the septum, and no tricuspid regurgitation. The blocker was released and the procedure was completed. After the operation, Lin Lin recovered well, and at the one-month follow-up, the cardiac ultrasound showed that the blocker was well positioned, with no residual shunt and no peripheral structures affected. The electrocardiogram was normal.