Anal fissure and internal hemorrhoids are a combination of two anal diseases. Anal fissure may be caused by abnormal bowel movement, spasm of the internal anal sphincter, etc. It can be treated with topical antibiotics of macrolides, anti-inflammatory and analgesic drugs. Internal hemorrhoids may be caused by abnormal bowel habits, which can be treated by enhancing venous tone and other drugs. 1. Stool abnormalities: mainly due to coarse and hard feces, resulting in anal canal skin fissure, if it is long-term diarrhea, may also lead to anal fissure phenomenon. Under the guidance of the doctor, the anus can be cleaned by potassium permanganate solution and treated with topical macrolide antibiotic drugs, such as erythromycin ointment. 2. Spasm of the internal anal sphincter: due to the stimulation of inflammation, the muscle tension of the internal anal sphincter increases, leading to the occurrence of anal fissure. It can be treated with anti-inflammatory and analgesic drugs, such as diclofenac sodium delayed-release tablets, levofloxacin hydrochloride capsules, etc., and the specific use of medication should be in accordance with the doctor’s instructions. 3. abnormal defecation habits: such as long-term constipation, stool too much struggle, squatting toilet too long, etc., may lead to internal hemorrhoids, can be enhanced through the venous tension class, topical macrolide antibiotics and other medications for treatment, such as dioxymethamphetamine tablets, erythromycin ointment and so on. The patients who have anal fissure, internal hemorrhoids, should go to the hospital in a timely manner, under the guidance of the doctor to clarify the cause of the disease, choose targeted drugs for treatment.