Skin test is the abbreviation of skin (or intradermal) sensitivity test, which is a kind of specific test commonly used in clinical practice, mainly to test whether it will cause allergic reaction before using the drug. The main methods of skin test include intradermal injection, patch test and prick test, among which intradermal injection method is more commonly used. The skin test is of great importance to prevent the occurrence of serious allergies, so patients should actively cooperate during the treatment of drugs. In order to prevent the occurrence of allergic reactions, the relevant authorities require some drugs that are prone to allergic reactions to undergo skin testing before use, and common skin testing drugs include penicillins, streptomycins, etc. The sensitivity of drugs varies among individuals. The skin test is performed by injecting a small amount of the drug between the epidermis and the dermis, and the patient usually needs to be observed for about 20 minutes after the application of the drug, avoiding strenuous movement during the period. Some patients may have allergic reactions, such as local papules become larger, red, itching, etc., more serious cases may also appear dizziness, pale, chest tightness, shortness of breath, panic, shock, etc., then the skin test results are positive, can no longer use the drug to avoid adverse consequences. Allergic reactions should be promptly reported to the health care personnel, and appropriate treatment should be taken in time to prevent dangerous situations from occurring.