1.General principles of treatment: Consider the clinical manifestations of the patient’s peripheral neuropathy, assess the degree of ulceration of the nonsensory foot, and provide general knowledge of foot care; patients with diabetic peripheral neuropathy require regular, long-term follow-up, especially regular foot examinations. 2.Commonly used pharmacological treatment methods: The aim is to reduce the rate of disability while preventing complications: (1) Allopathic treatment: ①Glucose control: Active and strict control of hyperglycemia and keeping blood glucose stable are the most important measures to prevent and treat DPN. Rapid changes in blood glucose can aggravate or induce neuropathic pain in patients, and strict glycemic control can reduce the 5-year risk of diabetic peripheral neuropathy by 60%. ②Nerve repair: Nerve damage in DPN is usually accompanied by segmental demyelination and axonal degeneration, and its repair is often a lengthy process, such as repairing axonal degeneration takes up to 18 months. It is mainly through enhancing the synthesis of nucleic acid, protein and phospholipid in nerve cells to stimulate axonal regeneration and promote nerve repair. Commonly used drugs include methylcobalamin, etc. (3) Anti-oxidative stress: By inhibiting lipid peroxidation, increasing blood flow to neurotrophic vessels, increasing neural Na+-K+-ATPase activity and protecting vascular endothelial function. Commonly used drugs such as a-lipoic acid. ④Improve microcirculation: improve blood supply and oxygen supply to nerve cells. Commonly used drugs such as prostaglandin E2, hexoketococine, scopolamine, cilostazol, blood-activating and stasis-transforming herbs, etc. ⑤ Improving metabolic disorders: It works by reversibly inhibiting aldose reductase. New generation aldose reductase inhibitors such as epalrestat. (6) Others: such as neurotrophic, including neurotrophic factor, C-peptide, inositol, gangliosides and linolenic acid, etc. (2) Symptomatic treatment: The following sequence is usually used to treat patients’ pain symptoms: methylcobalamin and a-lipoic acid, traditional and new generation anticonvulsants, duloxetine, tricyclic antidepressants, opioid analgesics, etc. ①Methylcobalamin and a-a-lipoic acid: can be used as the first stage of symptomatic management; ②Traditional anticonvulsants: mainly sodium valproate and carbamazepine; ③New generation anticonvulsants: mainly pregabalin and gabapentin; ④Tricyclic antidepressants: commonly used amitriptyline, promethazine and the new antidepressant cetepram, etc.; ⑤Opioid analgesics: mainly oxycodone and tramadol, etc.; ⑥Local analgesics: mainly (6) local painkillers: mainly used for those with limited pain. For example, isosorbide nitrate spray thorn and glyceryl trinitrate patch can reduce local pain and burning sensation; capsaicin can reduce the release of painful substances; local application of 5% lidocaine patch can also relieve pain. According to the U.S. 2011 guidelines for the treatment of painful diabetes: first-line drug pregabalin, second-line is a combination of gabapentin and griseofulvin. Third-line drugs are opioids. And traditional anticonvulsants may not be very useful.