Sertraline can be used to treat premature ejaculation. Sertraline is a selective 5-hydroxytryptamine reuptake inhibitor, clinically used mainly for depression treatment. However, in patients with premature ejaculation, the effect of prolonging ejaculation can be achieved by selectively blocking the reuptake of 5-hydroxytryptamine and increasing the concentration of 5-hydroxytryptamine in the central nervous system. Sertraline belongs to this class of drugs, so the clinical treatment of premature ejaculation may use sertraline. Sertraline treatment for premature ejaculation needs to be taken for a long time to see the effect, but taking sertraline may appear dry mouth, headache, decreased libido, diarrhea, nausea, erectile dysfunction and other side effects, long-term use of the drug may also reduce the quality of male sperm and vitality. Premature ejaculation patients using sertraline need to be completed under the guidance of a doctor, do not self-medication. Premature ejaculation may also be caused by a number of diseases, you should consult a doctor in a timely manner to clarify the cause, under the guidance of the doctor for targeted treatment.