Interstitial nephritis is a group of diseases characterized by tubular atrophy, interstitial fibrosis and varying degrees of cellular infiltration. The mechanisms of interstitial renal damage can involve immune injury, infection, toxicity, metabolic disorders, mechanical obstruction of urinary flow, and genetic factors. Clinically, renal tubular impairment is the main manifestation, and chronic renal failure is manifested in the later stages of the disease. Prevention of interstitial renal injury: 1. Control of disease Patients with systemic diseases are prone to complications of interstitial nephritis, so it is important to control such diseases to prevent interstitial nephritis. Experts point out that systemic diseases include systemic lupus erythematosus, dry syndrome, nodular disease, primary cryoglobulinemia, hematologic diseases, such as multiple myeloma, paroxysmal hemoglobinuria, lymphoproliferative disorders, sickle cell disease, etc. 2, prevention of infection Bacterial infection is an important cause of interstitial nephritis, such as Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium diphtheriae, Mycoplasma, syphilis, brucellosis, legionellosis, hepatitis B virus antigen, cytomegalovirus, typhoid, measles, etc. Therefore, the prevention of infection, that is, the prevention of interstitial nephritis. 3, metal isolation Some data show that people with long-term exposure to heavy metals (cadmium, lithium, aluminum, gold, beryllium, etc.) are more susceptible to interstitial nephritis than normal people. Nephrologists emphasize that the prevention of interstitial nephritis, pay attention to the isolation of heavy metals.