When protein levels in the urine of newborns increase and can be detected by a routine urine test, it is called neonatal proteinuria. So how to prevent proteinuria in newborns? Attention should be paid to avoiding infections, especially upper respiratory tract infections; avoiding excessive exertion or mental tension; avoiding drug abuse, etc. Because of the deficiency of the disease, we should harmonize the spirit and nourish the body. Medical staff should provide a comfortable, quiet and fresh air environment for patients, and encourage patients to self-condition. Pay attention to keep the room clean and disinfect regularly to avoid cross-infection. Let the patient understand the basic knowledge of the disease, do not use the color of urine as the only criterion to judge the condition and generate fear, should make appropriate explanation and comfort.