People with diabetic neuropathy can have a knee replacement if their blood sugar is well controlled. People with diabetic neuropathy who have poor glycemic control have an increased risk of knee replacement surgery, mainly due to poor glycemic control, poorer blood supply to the wound, which is not easy to heal, and easy to combine with postoperative infection. For diabetic patients, hypoglycemia and severe hyperglycemia should be avoided, and it is recommended that the blood glucose control should be below 7.8~10.0mmol/L. For severe and elderly diabetic patients, the blood glucose control can be relaxed to ≤12mmol/L, which will help the postoperative recovery, and for diabetic neuropathy people with good blood glucose control, it is possible to carry out the knee joint replacement surgery. It is recommended to actively cooperate with the doctor’s medication sugar-lowering program before the operation, control blood sugar at 7.8~10.0mmol/L, and perform the operation after the professional doctor’s evaluation; after the operation, actively carry out the rehabilitation training, and consult the doctor in time when there is any discomfort so as to avoid delaying the condition.