From November 2002 to May 2007, the Ninth People’s Hospital of Shanghai received a total of 26 cases and 34 wounds from the Department of Plastic Surgery. A total of 34 wounds were selected from 26 patients with post-burn scar contracture deformity and traumatic large skin defects. For various wounds (scar excision and release, burns, traumatic skin defects, large body surface tumor excision wounds), thorough hemostasis and debridement were performed, and after 1 week of wet dressing and dressing change, the wounds were covered by composite graft of ADM and autologous large-edge thick epidermis, and the healing ability was observed, and postoperative scar proliferation (Vancouver score , histological test) and functional recovery to evaluate the clinical efficacy. Of the 34 wounds in 26 patients, all were mostly viable (≥90% area) except for 2 wounds with skin fragments >10% necrosis. ADM and autologous large-edge thick epidermal thin skin composite grafting can save skin source and reduce scarring in the donor area, which is a minimally invasive treatment modality suitable for a variety of wounds and has the potential to replace medium-thickness skin grafting.