Fatty liver in general can donate blood. Fatty liver is not a contraindication to blood donation, and the main lesion of fatty liver is in the liver, not in the blood system. The main lesion of fatty liver is in the liver, not in the blood system. Generally, when fatty liver is mild or moderate, the decline in liver function is not obvious, and the impact of blood donation on the body is not significant and can be quickly recovered through blood regeneration. However, if fatty liver is also combined with various infectious diseases transmitted by blood, you cannot donate blood, for example, when syphilis, AIDS, hepatitis B, hepatitis C, you cannot donate blood because various viruses can be transmitted to others through blood. In addition, if the fatty liver progresses to fatty cirrhosis, you should not donate blood because cirrhosis can lead to hypersplenism, anemia and platelet decline, and various complications of cirrhosis can also occur, which prevent you from donating blood. The liver is a hematopoietic organ and its hematopoietic capacity is reduced in cirrhosis, which can aggravate anemia. When most of the liver is accompanied by hypersplenism, platelets are reduced, and if further blood donation leads to a further decrease in platelets, bleeding may be induced.