The development of a blood clot in a PICC line is a more serious condition. PICC tube usually refers to central venous catheter, which is usually delivered to the central vein through peripheral vein puncture. Once a thrombus occurs in this tube, it may lead to blockage of the vein, obvious limb pain and swelling, and sometimes the thrombus may also be dislodged, which is likely to block the veins in the heart, lungs, and the brain and other organs, and cause ischemic necrosis of the local tissues. If the condition requires the placement of PICC tube, you can follow the doctor’s instructions to use clopidogrel or warfarin and other anticoagulant drugs for regular treatment, and at the same time, you should also take appropriate rest and avoid over-exertion of the arm on the side of the tube, so as to actively prevent thrombus formation, and to prevent the later occurrence of infections, embolisms and other serious consequences.