Fungal infections of the palm of the hand that develop a significant inflammatory response or have fever with local changes of exudation, congestion, and edema should be promptly disinfected and debrided. A sterile dressing should then be applied for local dressing and regular dressing changes should be observed. It should also be combined with antifungal medication, commonly used is itraconazole tablets, and also with topical ketoconazole cream. If the patient has significant fever, there is also the option of giving intravenous antifungal medication, fluconazole injection. During the treatment period, care should be taken to stay away from smoking and alcohol consumption environments, as poor dietary habits can easily affect the healing of the wound and are not conducive to recovery. During the administration period, attention should also be paid to monitoring the changes of liver and kidney function indicators, because the commonly used antifungal drugs have a certain degree of hepatotoxicity and nephrotoxicity, so attention should be paid to prevention.