The thickest piece of flesh in the palm of the hand is the greater interphalangeal, there are many reasons for pain in the greater interphalangeal, excluding bumps and scratches and other traumatic pain, the main causes of pain in the greater interphalangeal include muscle strain or local inflammation, etc. It is best to determine the cause based on the actual performance and previous history of trauma. 1, hand muscle strain: If patients often have hand strain, or muscle wear caused by repeated pulling, it can lead to fasciitis of the hand, triggering pain in the large fissure. If the pain is short-lived, it may just be muscle fatigue, pay attention to timely rest; 2, infection: if the patient recently cut the skin of the hand by sharp objects, the surface of the pus boils, then consider the local septic infectious disease, this type of disease has more redness and pain of inflammatory manifestations, if not timely treatment may also appear general discomfort symptoms; 3, other diseases: exclude the wrist strain, infection, etc., but also consider the Local tumor compression of the greater interphalangeal area causes pain. In addition, some patients for professional reasons or habits, need to long-term, hard use of the thumb joint, so that the most vulnerable parts of the pain is the carpometacarpal joint, in the long run, it is easy to develop inflammation of the carpometacarpal joint, forceful pinching grip action will appear pain in the joint area, so that we think it is pain inside the muscle, but in fact, it is carpometacarpal arthritis.