When a thyroid nodule is found during a physical examination, it needs to be identified by a thyroid specialist. Most of the thyroid nodules found during physical examination are natural and do not require any treatment or management even if they are found. Which thyroid nodules found during physical examination should be considered as possible thyroid cancer? 1. Isolated thyroid nodules should be clinically excluded from thyroid cancer. 2.Surgical palpation of hard and uneven nodules with enlarged cervical lymph nodes. 3.Companied by paralysis of the recurrent laryngeal nerve or previous history of neck radiation. 4. One nodule is found to be particularly prominent and hard among multiple nodules in the thyroid gland. 5. In the description of thyroid ultrasound, the nodule is hypoechoic with irregular morphology, burr-like changes around it, abundant blood flow around it, gravel-like calcifications, and papillary-like structures within the nodule should be considered as a possible thyroid cancer.