Ibuprofen is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects, which can be used by both adults and children, and is more effective in reducing fever for inflammatory fevers. It is mainly used for fever caused by common cold and influenza, so if the fever is caused by other reasons or unknown reasons, ibuprofen should not be chosen to reduce fever to avoid toxic side effects. However, it should be noted that if the following contraindications occur, ibuprofen should be used with caution: 1, ibuprofen antipyretic effect is relatively strong, the process of antipyretic will lead to a large amount of sweating, if the patient has symptoms of dehydration, it is not suitable for ibuprofen; 2, ibuprofen metabolized through the kidneys, if the patient has renal dysfunction, it should be taken with caution. Healthy patients should pay attention to the dosage, so as not to overdose and cause kidney damage; 3, patients with allergic diseases, immune system diseases and blood system diseases, etc., should consult a doctor before taking the drug; 4, patients with gastric hemorrhage, gastric ulcers, gastric perforation and other diseases, the dose of the drug should be controlled, so as not to overdose, so as not to aggravate the patients’ gastric diseases. In addition when consuming ibuprofen, it should be noted that if the patient has fever, not to take two fever-reducing drugs at the same time. After taking ibuprofen, there is no immediate cooling, you can take physical fever reduction methods, such as rubbing bath method, ice packs cold compresses and so on. In addition, due to ibuprofen in the process of fever reduction, the patient sweats more, therefore, after taking the drug patients should be timely supplemental water, so as to avoid the occurrence of dehydration.