Malignant oral ulcers are large lesions, up to 10-30 mm in diameter, reaching depths from the submucosa to the muscularis, with long episodes that can last up to several months. The ulcers cause significant pain and leave scarring after healing, even forming tissue defects on the tip of the tongue and the uvula. Treatment requires cauterization of ulcer edges with 10% silver nitrate or 50% trichloroacetic acid solution to remove necrotic tissue, and submucosal closure injection with tretinoin or prednisolone acetate suspension to relieve pain and promote healing, along with microwave and laser treatment to speed up healing, and systemic application of adrenocorticotropic hormone to promote healing and repair of epithelial tissue.