Ibuprofen extended-release capsules are useful in the treatment of vascular headache because it is an enzyme drug that mainly inhibits the synthesis of prostaglandins, because the rise in the amount of prostaglandins causes pain, and this vascular pain is caused by the increase in the release of inflammatory mediators brought about by vasospasm or inappropriate dilation, and ibuprofen acts precisely on the headache caused by the increase in the release of inflammatory mediators, so ibuprofen Therefore, ibuprofen has a certain effect on vascular headache. But the key is to deal with the source of vasogenic headache. Although ibuprofen has an effect, more often drugs that regulate vascular function, such as antanine or ergometrine, are used to regulate vasodilation to relieve vasogenic headache, and calcium channel modulators are also used to reduce central sensitization to increase the release of endogenous opioid peptides. Enzymes like ibuprofen, because they are enzymes, cause a decrease in prostaglandin release and will provide good pain relief. However, the enzyme drugs like ibuprofen often cause adverse side effects such as gastrointestinal tract, because prostaglandins can increase the blood supply of the gastrointestinal mucosa, and prostaglandins can also help the release of bicarbonate from the gastrointestinal mucosa, which can play a good role in helping to protect the gastric mucosa. However, the use of enzymes will block prostaglandin synthesis, so its release will be reduced, thus reducing the protective effect of the gastric mucosa and intestinal mucosa, so it may cause complications such as gastrointestinal tract, while prostaglandins and other aspects of cardiovascular stability, platelet function and other important role, so patients with coronary heart disease should be very cautious when using it, and it is generally recommended that patients over 75 years of age avoid it, because it will increase Cardiovascular adverse events occur as well as increase the occurrence of gastrointestinal adverse events. And there are also patients with serious deficiencies in liver and kidney function should also use enzymes with caution, and it is best not to use them. Also do not use two enzymes at the same time, because there will be a ceiling effect, mainly refers to the increase in the dose and type, the adverse effects will also increase significantly, but the strength of the effect will not continue to improve, so it is called the ceiling effect, so avoid the use of more than two enzymes at the same time. At the same time, for patients over 75 years old, try to avoid the use of enzymes, and when you have to use enzymes, consider using topical patches or creams, which can also serve the purpose of pain relief. Patients with cardiovascular instability, ulcers in the gastrointestinal tract, and patients with chronic gastroenteritis should also avoid their use.