Spider nevus may be associated with changes in estrogen levels in the body, and in patients with liver disease it may be due to recurrent episodes of the disease. Spider nevus is an idiopathic capillary dilatation formed by the expansion of the end section of small arterial branches of the skin, and its occurrence is mostly considered to be related to the elevated level of estrogen, which is mainly manifested as a center point in the middle of the nevus, surrounded by radial small blood vessel branches, resembling the shape of spiders. Liver has certain inactivation effect on estrogen, and the occurrence of spider nevus is mostly considered to be related to acute and chronic hepatitis, cirrhosis, liver cancer and other liver diseases, and spider nevus may be caused by recurrent episodes of the patient’s condition. For example, patients with liver cirrhosis in the decompensated stage, the function of liver cells is severely damaged, spider nevus may appear, after treatment, the function of liver cells will be improved, the spider nevus may disappear, and when the condition worsens, it may reappear again, resulting in the spider nevus sporadic and recurring episodes. In addition, estrogen level in pregnant women will also increase to a certain extent, and with the change of estrogen level during pregnancy, spider nevus may also appear sporadically. If a patient has spider moles that are sporadic or recurring, it is recommended that he or she consult a doctor in time to find out the cause of the disease and carry out targeted treatment, so as to avoid delaying the condition.