Perhaps influenced by the “old military doctors” on the telephone poles, many patients with poor self-awareness of their sexual intercourse satisfaction often complain that they may be suffering from impotence and premature ejaculation when they seek medical attention, and a few doctors confuse this with the same thing. Here, first of all, it is important to make it clear that impotence is impotence and premature ejaculation is premature ejaculation. Impotence is mainly focused on erection, such as: lack of erectile hardness, difficulty in erection, inability to get an erection, and inability to maintain an erection for a satisfactory sex life, hence the scientific name of impotence is also called erectile dysfunction. Premature ejaculation, on the other hand, is a more complex syndrome. Patients with premature ejaculation have a short interval between penile entry into the vagina and ejaculation, often less than one minute in many patients. In addition, they have serious problems with the control of ejaculation, i.e., this action occurs before they are willing to ejaculate. Therefore, when a doctor sees a patient, he or she needs to make a strict distinction between the conditions, and even if the patient suffers from both impotence and premature ejaculation (which, it should be noted, is not uncommon), a very individualized treatment plan that meets the patient’s needs should be developed, depending on the patient’s specific situation, so that it can really help the patient. In the case of impotence, PDE5 inhibitors are familiar therapeutic drugs, whose main function is to improve penile hardness and do not help in controlling ejaculation. For the treatment of premature ejaculation, the development trend shows that medication has replaced psychological and behavioral treatment as the mainstream treatment for premature ejaculation. In terms of drug safety, the new short-acting selective 5-hydroxytryptamine reuptake inhibitors, represented by Brylcreem, have undergone rigorous clinical safety verification and a large number of case observations for their toxic pathology and adverse reactions, so there is no need to worry too much as long as the patient follows the medical advice and instructions.