When people think of depression, the typical symptoms of “three lows”, i.e. depressed mood, slowed thinking and reduced volitional behavior, as well as loss of appetite, weight loss and insomnia are also familiar to everyone. However, in clinical practice, we do see some patients with depressive episodes with atypical features, which we call “atypical depression”. This is a diagnostic name for the illness, not a general term for depression with atypical symptoms. Atypical features include: improved mood in response to real or potential positive events; significant appetite or weight gain; increased sleep; lead-like paralysis (i.e., a lead-like feeling of heaviness in the upper and lower extremities); increased sensitivity to rejection, i.e., pathological sensitivity to rejection by others, manifested as hatred of others, or deliberate abdication of important responsibilities, or avoidance of interpersonal interactions. We consider a depressive episode to have atypical features if it is accompanied by the above-mentioned manifestations. However, the diagnosis of atypical depression requires a rigorous assessment and judgment by a specialist. Atypical depression is often overlooked because of its atypical features. If you are depressed with the above-mentioned symptoms, you should also pay attention to them.