The 21-year-old Pan (a pseudonym) loves the Internet and often stays up all night, with a bottle of carbonated beverages overnight, thinking that life is dashing and comfortable. He woke up one day with no strength in his limbs, his arms and legs were immobilized, and he was unable to walk even with the help of his friends. Since the beginning of summer, the incidence of hyperthyroidism periodic paralysis has increased significantly as the weather gets hotter. As the name implies, hyperthyroid periodic paralysis is a comorbidity of hyperthyroidism, and in China, it is more common in men than in women. Because patients are likely to be unaware that they are suffering from hyperthyroidism, coupled with prolonged late nights, fatigue, and large amounts of carbonated beverages, they eventually develop weakness in their limbs and even become completely immobilized like Pan. Hyperthyroidism is a series of hypermetabolic syndromes caused by the pathological synthesis and secretion of excessive thyroid hormones by the thyroid gland, which eventually acts on the whole body. It is often characterized by excessive sweating, fear of heat, hyperphagia, weight loss, palpitations, impatience, fatigue, thickening of the neck, protruding eyes, and so on. Sometimes it can also manifest as eating more but not gaining weight, feeling more comfortable in the cold season, subtle tremor in the hands, muscle weakness, emotional instability, easy fatigue after activities, poor concentration, memory loss, low efficiency in work and study, etc. We would like to remind you that “the muscle weakness of the limbs shown by Xiao Pan is one of the typical comorbidities and clinical manifestations of hyperthyroidism. When the above symptoms appear, you should go to the endocrinology and metabolism department of the hospital in time to improve the relevant examination so as to provide timely treatment and avoid the occurrence of serious comorbidities.” Active prevention and early treatment Hyperthyroidism periodic paralysis is characterized by recurrent episodes of limb weakness, often accompanied by low blood potassium. The patient’s muscle weakness symptoms can usually be relieved after the blood potassium is replenished and normalized. Common precipitating factors include fatigue, full meals, large amounts of high-sugar foods, alcohol abuse, mental stimulation, and excessive exercise. As a reminder, “while avoiding the above triggers, patients need to eat potassium-rich foods, such as oranges, bananas, etc., to actively prevent the occurrence of hypokalemia. If necessary, potassium chloride medication can be taken as soon as the symptoms of muscle weakness appear, and the patient should seek medical attention after the symptoms have subsided. As hyperthyroidism worsens, periodic paralysis is likely to reoccur, so when unexplained limb paralysis occurs, it is important to seek prompt medical attention for early treatment.”