For the treatment of Meige syndrome, there is no cure at home and abroad, whether it is medication or surgical treatment at present the main improvement and control of symptoms to improve the quality of life. At present, domestic and foreign use of the medial nucleus of the pallidum DBS treatment of Meige syndrome, foreign reports of 42 cases, Lyons et al. reviewed 20 patients reported in the literature from 2001-2010, BFMDRS improvement rate of 20-80% (> 12 months average improvement rate of about 66.85%). Reese et al. conducted a multicenter retrospective study with long-term (>78 months) follow-up of 12 patients with Meige syndrome who underwent bilateral DBS of the medial nucleus of the pallidum, with an average symptom improvement rate of about 53%. On the basis of foreign studies, combined with our own research experience in the past ten years, we have improved the foreign surgical method combined with the specific conditions of the patients, and adopted personalized deep brain electrical stimulation therapy, with different stimulation targets (medial nucleus of the pallidum, thalamus floor nucleus, etc.) for different patients, which has greatly increased the effectiveness and efficacy, and is effective in about 80-90% of the patients with the improvement rate of 77-100%, which is higher than that of foreign purely medial nucleus of pallidum DBS treatment, which has an average of 53%. The improvement rate is around 77-100%, which is significantly higher than that of foreign DBS of the medial nucleus of the pallidum alone. At the same time, DBS treatment for Meige syndrome can also improve patients’ obsessive-compulsive, anxiety and depression symptoms, which significantly improves patients’ quality of life and brings new hope to patients’ work, study and life.