A positive T-SPOT test is not directly related to infectiousness. a positive T-SPOT test can only reflect infection with Mycobacterium tuberculosis, but cannot determine whether it is a previous infection or a recent infection, and is not related to the size of infectiousness. At present, the size of infectiousness mainly depends on the results of sputum examination. Patients with positive sputum bacteria are more infectious, especially those with a large number of Mycobacterium tuberculosis detectable in sputum, which is the most infectious. Such patients need to be treated in isolation in a timely manner, and attention needs to be paid to the management of sputum and ventilation of the room. Anti-tuberculosis treatment is the key. Generally, after regular anti-tuberculosis treatment, its infectiousness will be significantly reduced.