Whether a burn blister will go away on its own without being picked needs to be analyzed on a case-by-case basis, and cannot be generalized. If the blisters are relatively small and the symptoms are mild, they will generally be absorbed by the body’s tissues and disappear in a week or so. If the burns are extensive and the blisters are large, affecting daily life or work, the contents of the blisters need to be pumped out or picked through with sterile gauze under strict disinfection to protect the wound and promote healing, which usually does not disappear on its own. If the blisters are large and fused between them, the exuded plasma denatures and becomes jelly-like in the blister fluid. With external colonizing bacteria infection, it is easy to form subcutaneous pus and fluid accumulation, which aggravates the infection and is not conducive to wound healing. Patients with burns can apply scald ointment under the guidance of a doctor, pay attention to protecting the trauma, do not get wet, eat a light diet, avoid eating spicy and stimulating food, and avoid smoking and alcohol.