Intractable psoriasis is mainly treated by removing causative factors, medication and physical therapy. 1. Remove causative factors: stubborn psoriasis, recurrent attacks, consider and causative factors are not removed, such as the presence of tonsillitis, pharyngitis or upper respiratory tract infection, etc., should be clear causative factors, active treatment, so as to be able to avoid recurrent attacks. 2. Drug treatment: you can apply topical treatment with glucocorticoid drugs such as trimethoprim and mometasone furoate cream, or vitamin D3 derivatives such as carbotriol, and combine with methotrexate and cyclosporine to regulate the immune system if necessary. If the drug treatment of moderate to severe psoriasis is ineffective, you can use biological agents such as adalimumab for treatment. Specific medication should follow the doctor’s instructions. 3. Physical therapy: photochemotherapy, narrow-spectrum medium-wave ultraviolet phototherapy, 308nm excimer laser and other physical methods can be used for treatment. Intractable psoriasis should be treated correctly in strict compliance with the doctor’s instructions, to avoid recurrent attacks, affecting the life.