Stage II diabetic nephropathy usually cannot be controlled for a lifetime, and renal function will slowly decline, which will eventually lead to uremia in some patients, and active treatment may slow down this process.
Diabetic nephropathy is one of the most common microvascular complications of diabetes. Glomerular hypertrophy, mild thickening of the glomerular basement membrane, and mild widening of the tethered zone can be seen under light microscopy in the early stage. With the progression of the disease, the glomerular basement membrane is diffusely thickened and the stroma is proliferated, forming typical K-W nodules.
Diabetic nephropathy stage II is seen as persistent microalbuminuria with normal or elevated GFR and clinical asymptomatic. Renal pathology glomerular/tubular basement membrane thickening, widening of the tethered zone, etc. If actively lowering glucose, blood pressure and urinary proteins treatment, patients’ renal function declines at a relatively slow rate, and it may take decades to progress to end-stage renal disease.
If the treatment is not timely, patients will progress to end-stage renal disease within several years and need renal replacement therapy such as hemodialysis and peritoneal dialysis.
Patients with diabetic nephropathy need to undergo regular review and strict control of blood glucose and blood pressure under the guidance of specialists to reduce urinary protein and try to slow down the rate of progression of nephropathy.