According to the guidelines of the Chinese Medical Association Endocrinology Branch and Nuclear Medicine Branch on the diagnosis and treatment of thyroid diseases, the following nine types of hyperthyroidism are the best choice for iodine-131 treatment: 1. 5. Hyperthyroidism with leukocytosis and/or thrombocytopenia; 6. Hyperthyroidism in old age; 7. Hyperthyroidism combined with diabetes mellitus; 8. Toxic multinodular goiter; 9. Functional autonomic thyroid nodules combined with hyperthyroidism. However, the following patients with hyperthyroidism should be treated with iodine-131 with caution: 1) adolescents and children with hyperthyroidism, who have failed treatment with ATD, refused surgery or have contraindications to surgery; 2) hyperthyroidism combined with more severe impairment of liver, kidney and other organ functions; 3) infiltrative proptosis. Iodine-131 alone can be used to treat mild and stable moderate to severe infiltrative synostosis. For patients in the progressive stage, hormone preparations can be added as an adjunct before iodine-131 treatment. Iodine-131 therapy is contraindicated in the following patients with hyperthyroidism: 1) women during pregnancy; 2) nursing mothers; 3) hyperthyroidism with extremely severe liver or kidney disease or myocardial infarction and other serious systemic diseases; 4) others.