Hodgkin’s lymphoma and non-Hodgkin’s lymphoma are both malignant tumors of the immune system. They have similarities and obvious differences, and their differences include: First, the incidence rates are different, Hodgkin’s lymphoma accounts for about 30% of all lymphomas; non-Hodgkin’s lymphoma accounts for about 70% of such all lymphomas. The age of onset is different: Hodgkin’s lymphoma is more common in young patients; non-Hodgkin’s lymphoma is more common in older patients. Clinical manifestations are different. Hodgkin’s lymphoma is often characterized by painless enlargement of lymph nodes as the first symptom, which is commonly found in the neck, supraclavicular, axillary and inguinal areas; in non-Hodgkin’s lymphoma, in addition to enlargement of lymph nodes, extra-nodal invasion is more common, often invading the digestive system, nervous system, urinary system and so on, resulting in a series of symptoms. Fourth, the treatment options for Hodgkin’s lymphoma and non-Hodgkin’s lymphoma are different. The common option for Hodgkin’s lymphoma is the ABVD option, and the common option for non-Hodgkin’s lymphoma is the CHOP option.