If a patient has difficulty urinating due to prostate enlargement, alpha blockers are usually used as the drug of choice for the treatment of difficulty urinating due to prostate enlargement. Tamsulosin or doxazosin are commonly used in the clinic, and their main action is to block the smooth muscle spasm and contraction mediated by alpha blockers. By using doxazosin or tamsulosin, relaxation of urethral smooth muscle, dilation of the urethra, and reduction of pressure in the urethra can be achieved, which leads to the effect of unblocked urination and the relief of the patient’s symptoms of dyspareunia. In addition to the use of alpha-blockers, patients are advised to take 5 alpha-reductase inhibitors such as finasteride at the same time, and the 2 drugs are treated simultaneously to achieve better results in the treatment of prostate enlargement.