The existence of H. pylori is not new to us. In clinical practice, many patients with gastric disease are found to have H. pylori, and some people without digestive symptoms are also found to have H. pylori infection during routine medical examinations. What is H. pylori? What are the effects of its presence on the human digestive system? What should I do if I am infected with H. pylori? First, we need to know what H. pylori is. H. pylori is a gram-negative, microaerobic bacteria, since the Nobel Prize in physiology and medicine in 2005, Warren and Marshall in 1979 from chronic gastritis patients in the gastroscopic biopsy specimens isolated Hp, and from many studies found that H. pylori and a number of digestive tract diseases have a close link. infection has a global distribution and is an important causative factor for chronic gastritis and gastroduodenal ulcer, and is closely related to the occurrence of gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma, which has been classified by the World Health Organization as a class of pathogenic factors. Therefore, in clinical practice, treatment was once given when H. pylori was seen to be positive. However, with the development of medical treatment and more in-depth research on H. pylori, it has been found that 50% of the world’s population carries H. pylori, and in some regions even 80% of people carry these bacteria. Yet only 10 percent of carriers develop peptic ulcers and only about 1 percent develop stomach cancer. Do we really want to kill off H. pylori? Many studies have shown the possible protective effect of H. pylori on the body, and some studies have reflected the problems that can occur after eradication: more than 50% of patients experience adverse reactions during eradication; about a 20% chance of eradication failure; changes in intestinal flora after eradication may have long-term health effects; and the use of antibiotics increases the risk of drug-resistant bacteria. Even, some clinical patients cannot tolerate PPI and experience the side effect of high gastric acidity after stopping the drug, which aggravates the symptoms of acid reflux. Therefore, it is necessary to understand under what circumstances Hp needs to be treated. According to the fourth national consensus report on the management of H. pylori infection, the recommended indications and recommended intensity for Hp eradication are as follows: Life precautions: 1. To change the way of eating, it is advisable to choose the meal sharing system or use communal chopsticks. 2.To drink boiled water instead of raw water, eat cooked food instead of raw food, and milk should be sterilized before drinking. 3, experimental evidence, ulcer patients and people kissing, but also the risk of spreading the disease, should be vigilant. 4, to develop good hygiene habits, to wash their hands before and after meals. Often used tableware must also be strictly disinfected. 5. Do not put cleaning products such as toothpaste in the bathroom, but put them in a ventilated place. Conclusion Hp has been symbiotic with humans for a long time (about 58,000 years) and is also a member of the normal stomach flora. Exploring the simple linear relationship between digestive tract diseases and Hp cannot yield satisfactory results, and we should also make more efforts to explore the integrated factors of the occurrence of digestive tract diseases. Therefore, when we face Hp infection, we should not be afraid of it and then kill it, but should make a more reasonable judgment in the context of individual digestive diseases and systemic conditions, and the continuous medical progress will give us better answers about Hp intervention. We may be able to shift the treatment of H. pylori from eradication to prevention – that is, maintaining a normal GI flora, identifying low or no pathogenic strains of H. pylori as a vaccine, and maintaining a healthy diet and lifestyle to prevent H. pylori infection.