In the early stage of severe pancreatitis infection, mainly aseptic inflammation is dominated by the release of a variety of inflammatory mediators and toxic substances due to necrosis of the intestinal pancreas, which will cause a mild increase in body temperature in the early stage of the patient, accompanied by a more pronounced abdominal pain, and at this time the main focus is on the prophylactic use of antibiotics. In the middle and late stages of the disease, if the disease is prolonged and aggravated, pulmonary infection and abdominal abscess formation, i.e. peripancreatic abscess, may occur. In case of pulmonary infection, the patient will show signs of increased body temperature, coughing and sputum, decreased oxygen saturation and lowered oxygen level in the body. After the formation of peripancreatic abscess, the patient may have abdominal mass and abdominal pain along with persistent high fever. At this time, it is necessary to use broad-spectrum adequate antibiotics for symptomatic treatment, anti-infection treatment, and even blood purification adjuvant treatment methods to actively control the infection.