The main therapeutic drugs for lymphatic metastasis occurring in lung cancer are chemotherapeutic drugs, targeted drugs and immune drugs. Chemotherapy is the most commonly used drug for the treatment of lymphatic metastasis of lung cancer, and it is often applied in combination, which can reduce the difficulty of surgery before operation and improve the prognosis after operation. Targeted drugs are relatively new treatment modalities, patients need to undergo genetic testing or use broad-spectrum anti-tumor vasopressor drugs, which can achieve better efficacy. Immunotherapy is mainly an option when other treatments are ineffective, and some patients can benefit. In recent years, chemotherapeutic drugs and immune drugs can also be used in combination, which can further improve the prognosis, but also pay attention to the situation of adverse reactions.