Currently, our commonly used regimen is the XELOX regimen: 1, a total of 6-8 courses of post-operative therapy, reduced as appropriate in the elderly or in poor health or with greater side effects of chemotherapy. 2, preoperative neoadjuvant chemotherapy for a total of 2-4 courses, after each 2 courses to assess the patient’s disease status. 3, a course of treatment for 21 days, the first day of each course of hospital infusion, chemotherapy drug is oxaliplatin, there are some antiemetic, hepatoprotective and some other adjuvant drugs. At the same time oral Xiloda (generic name: Capecitabine tablets), usage is generally twice a day, the dosage of doctors will be calculated according to weight, generally speaking, adults in China is 3-4 tablets each time. 4, chemotherapy side effects: The most common is the abnormal blood and liver function, which is the main reason for requesting blood draw before each chemotherapy. If the white blood cells are reduced, you generally have to use a granulocyte stimulating factor type of drug, and if the platelets are reduced, you need to use thrombopoietin, the treatment of thrombocytopenia is generally more expensive, and thrombopoietin is more expensive. Another more common side effect of this regimen is hand-foot syndrome, the manifestations of which are closely related to varying degrees, and commonly include numbness, dullness of sensation, abnormal sensation, tingling sensation, painful absence or persistent painful sensation. The treatment can generally be oral vitamin B6 can be, and oral chemotherapy drugs used at the same time, a maximum amount of up to 10 tablets, some patients often think that the doctor prescribed the wrong, once to eat ten tablets, not a day on twenty tablets, many patients often reduce the amount without permission, in fact, there is no mistake, please do not worry. Liver function and abnormalities are mainly transaminases elevated more common, elevated not much to worry about, you can give oral or intravenous hepatoprotective drugs, if the elevation is very obvious, the effect of hepatoprotective treatment is not good, you can consider postponing chemotherapy, from the experience, postponing chemotherapy on the overall efficacy of limited impact.