Some hepatitis B can develop into cirrhosis, and the proportion of hepatitis C transforming into cirrhosis seems to be higher. It is generally believed that necrosis, inflammation, regeneration and fibrosis of hepatocytes are closely related to cirrhosis, and the persistence and replication of hepatitis virus is an important cause of hepatocyte necrosis and inflammation, and liver fibrosis is the basic pathway of hepatitis to cirrhosis. Therefore, it is currently believed that inhibition of viral replication and anti-fibrosis are the two key measures to prevent the transformation of hepatitis into cirrhosis. For the inhibition of viral replication, common alpha interferon, pegylated interferon (Peroxin), lamivudine, telbivudine, entecavir, adefovir, etc. can be used for hepatitis B virus, as detailed in the chapter on antiviral therapy in this book. For hepatitis C, common alpha interferon, pegylated interferon and virazole are currently used. For anti-liver fibrosis, western drugs include gamma interferon, cilipramine, and vitamin E. Commonly used Chinese herbal medicines include hepatic fulvicol, lotai and luo shu hepatic capsule, compound turtle nail soft liver tablet, compound dan shen, and Xiao Chai Hu Tang. Avoiding factors that cause aggravation or recurrence of hepatitis is also an important aspect of preventing cirrhosis, such as avoiding alcohol, overwork, mental trauma, poor diet, indulgence, avoiding liver-damaging drugs, and lack of sleep.