In the early stages after a bone infection, cephalosporin-based broad-spectrum antibiotics are needed. When local drug sensitivity tests and bacterial culture tests are done, antibiotics need to be used according to the results of the bacterial culture. When the bone becomes infected, it needs to be treated with broad-spectrum antibiotics because there may be no obvious pus production in the early stage, and the majority of cases are treated with cephalosporin antibiotics as long as there is no cephalosporin allergy. With the gradual development of the disease, there will be the production of purulent discharge, at this time it is necessary to do drug sensitivity tests and bacterial culture tests to determine the specific pathogenic bacteria, by doing laboratory tests to check out the sensitive antibiotics, choose the most sensitive antibiotics, for bacterial infection to do further treatment.