At present, there is no specific therapeutic drug for rheumatoid factor. We should further clarify the cause of the elevated rheumatoid factor and choose therapeutic drugs according to the cause of the disease. The common causes of high rheumatoid factor are rheumatoid arthritis, systemic lupus erythematosus and other diseases, among which the commonly used drugs for rheumatoid arthritis are meloxicam, methotrexate, etc. Rheumatoid factor is an autoantibody that targets degenerated IgG. Rheumatoid factor is a kind of autoantibody with denatured IgG as the target antigen, and this test is of great significance for the diagnosis of rheumatoid arthritis. In addition to rheumatoid arthritis, positive or elevated rheumatoid factor can also be seen in connective tissue diseases such as systemic lupus erythematosus, scleroderma, dry syndrome, and some older people, and the cause of the rheumatoid factor should be clarified further in the presence of high rheumatoid factor. Different drugs can be used to treat different diseases that cause high rheumatoid factor, for example, the common drugs for rheumatoid arthritis are non-steroidal anti-inflammatory drugs such as meloxicam and ibuprofen, and anti-rheumatic drugs such as methotrexate and leflunomide. All of the above drugs should be used under the guidance of a physician, and it is recommended that patients with high rheumatoid factor go to the rheumatology and immunology department of a regular hospital to further clarify the diagnosis and follow the doctor’s instructions for treatment.