To evaluate the effectiveness of tonsillectomy in the treatment of IgA nephropathy (IgAN) in clinical remission and progression, Professor Wang Lining and his team at the Affiliated Hospital of China Medical University conducted a meta-analysis by collecting the results of all prospective and retrospective studies: the effectiveness of tonsillectomy as a combination therapy or alone in the treatment of IgA nephropathy. The analysis showed that tonsillectomy may reduce the rate of patients with IgAN going into end-stage renal disease (ESRD), and the study was published in a recent issue of AJKD. IgAN is the most common cause of glomerulonephritis worldwide, accounting for 20-45% of primary glomerular disease. the clinical course of IgAN varies from asymptomatic microscopic hematuria to rapidly progressive renal failure. 30-40% of patients with IgAN will progress to ESRD 20 years after diagnosis. even those with asymptomatic urine results that are less severe can progress to ESRD. Therefore, it is important to achieve clinical remission in patients with IgAN to prevent progression to ESRD. The data sources for this study were Pubmed database (1948 – May 2014), EMBASE database (1947 – May 2014), Cochrane Central Register (- May 2014). The keywords searched were “IgA nephropathy”, “glomerulonephritis, IgA”, “Berger’s disease” combined with “tonsillectomy” and “palatine tonsillectomy”. A total of 14 studies including 1794 patients with IgAN treated with or without tonsillectomy were included to compare the rates of clinical remission and progression to end-stage renal disease (ESRD) using a random-effects model. Analysis showed that patients with IgAN who underwent tonsillectomy had significantly higher clinical remission rates, and subgroup analysis of remission prognosis showed that tonsillectomy combined with hormone shock therapy was better than hormone shock therapy alone, tonsillectomy combined with conventional hormone therapy was better than conventional hormone therapy alone, and tonsillectomy was better than usual therapy. In addition, tonsillectomy was associated with reduced ESRD in patients with IgAN. This meta-analysis suggests that tonsillectomy may improve clinical remission rates and reduce the proportion of patients with IgAN who enter ESRD, either as a combination therapy or as a stand-alone treatment. However, this conclusion needs to be validated in a large, multicenter, randomized, controlled trial with a long follow-up period.