Reproductive specialist Hope Lee’s answer is no. First, let’s understand how many useful eggs there are in the ovaries. When we are babies, the ovaries have hundreds of thousands of small follicles, but not all of them are functional. By the time we reach puberty and have our first menstrual period, the number of eggs in the ovaries that are actually useful is determined, about 400. This means that we have about 30 years to welcome our great aunt every month. Then, let’s see how many follicles are sacrificed for the successful expulsion of an egg? With the action of pituitary hormones, there are several or more than ten follicles awakening and growing each month. The one that is most sensitive to pituitary hormones will grow rapidly with minimal hormonal stimulation, which is often referred to as the “dominant follicle”. The other follicles are not sensitive to pituitary hormones and require higher levels of pituitary hormones to grow, while being suppressed by the dominant follicle, which eventually has no chance to grow and is atretic. “When the dominant follicle grows up, it secretes estrogen and ovulates after maturation. The granulosa cells of the follicle left in the ovary form the corpus luteum, which secretes progesterone. As you know, the successful discharge of one egg in each menstrual cycle is accompanied by the silent death of several or even a dozen eggs. Finally, let’s talk about which eggs are promoted by IVF ovulation? The success rate of IVF is closely related to the number of eggs obtained, and within a certain range (≤15 eggs), the success rate increases with the number of eggs obtained. In each menstrual cycle, several or more than ten follicles are recruited, ending up with only one follicle growing and the rest being atretic, is this not a waste? The wise doctors then came up with the idea of ovulation promotion, where the follicles that would otherwise be atretic are allowed to grow by the use of ovulation-promoting drugs, so that many mature eggs can be obtained at once. This has increased the efficiency of IVF treatment! Moreover, the ovulation medication only affects the follicle growth and development of the current month’s menstrual cycle, and does not affect the follicles of subsequent menstrual cycles. So, of course, IVF ovulation promotion will not run out of eggs early.