The treatment of choice for giant cell tumor is surgical resection and radiation therapy. Only resection is possible to treat the tumor completely, and pathological examination should be performed to confirm the diagnosis and to replace the missing bone tissue with bone cement or implantation of autologous bone or allogeneic cancellous bone. If the tumor is large, amputation or other removal methods should be considered, because giant cell tumor is a malignant tumor, which has a very large scope of influence and may metastasize or spread when there is soft tissue infiltration. Radiation therapy can also be considered in the later stages, especially for giant cell tumor of bone after losing the chance of surgery, and radiation therapy is also effective for giant cell tumor of bone, but there are a few patients who can develop cancer after radiation therapy, so patients should be followed up for a long time after surgery or after radiation therapy. It is important to pay attention to the recurrence of the resection site of giant cell tumor of bone, or to cause lung metastasis and malignant changes.