Genital ulceration generally refers to the occurrence of genital ulcers, diabetic patients with genital ulcers treatment methods include blood sugar control, etiological treatment. 1. Blood sugar control: poor blood sugar control can induce various infections, so diabetic patients with genital ulcers need to follow the doctor’s instructions to take acarbose, metformin and other hypoglycemic drugs or injections of insulin therapy, combined with dietary control, appropriate exercise to keep the blood sugar control within a reasonable range. 2. Etiological treatment: genital ulcers caused by syphilis can be treated with benzylpenicillin, and those who are allergic to penicillin can be treated with ceftriaxone sodium; genital ulcers caused by genital herpes can be treated with antiviral drugs such as acyclovir and valacyclovir, and localized acyclovir cream and other medications can be used to apply. Diabetic patients who develop genital ulcers are advised to go to the hospital and ask the doctor to make a judgment and give a treatment plan.