Polyspermia refers to three consecutive semen analyses in which the total number of sperm or sperm density in each ejaculation is significantly higher than normal, and is usually referred to as polyspermia when the sperm density is greater than 250*106/ml. Because polyspermia is often accompanied by changes in some indicators of seminal plasma biochemistry, spermatozoa collide with each other and other reasons leading to decreased sperm viability and may lead to pregnancy failure. Therefore, polyspermia is considered to be a pathological category. The clinical incidence of polyspermia is not high and can be considered relatively rare, as first reported by Doefner (1962). Another scholar reported that a meticulous analysis of semen from 1374 infertile male patients found that patients with polyspermia accounted for about 38.7% of the infertility, which feels like a point high figure. It is also reported that polyspermia is associated with spontaneous abortion, and its cause of recurrent miscarriage may be the impaired maturation of the sperm nucleus, mainly because it cannot transmit genetic information to the embryo accurately and cannot maintain the normal development of the embryo well. Since the sperm nucleus has two major functions, one is to transmit genetic information from the parent to the offspring and the other is to maintain normal development of the embryo. Therefore, incomplete maturation of the sperm nucleus in patients with polyspermia is a very prominent problem. Research on polyspermia still needs to continue, and the principles of its treatment should follow the approach of promoting sperm nuclei maturation and improving sperm motility.